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InstitutionINSERM UMRS 872 - Institut National de la Santé et de la Recherche Médicale- Centre de Recherches des Cordeliers- UMRS 872- Université Paris VI Pierre et Marie curie
Institut National de la Santé et de la Recherche Médicale, Université Paris
Principal investigator Dr.Isabelle Dugail

Email: Isabelle Dugail

Telephone:+33 142-346922
Country France
Beneficiary NumberP04
About usThe INSERM UMRS 872 is a newly created multidisciplinary reseach center composed of

twenty research groups at the Cordeliers Research Center in Paris. The center associates staff members and laboratories from INSERM, Pierre and Marie Curie University (Paris 6) and René Decartes University (Paris 5). A strong research axis in this center is directed towards Nutrition and Metabolic diseases. The Cordeliers Research Center houses an animal facility and imaging equipments with confocal and electronic microscopy. The research objectives of the group in Paris are focussed on the understanding of lipid metabolism and trafficking in the adipocyte and their dysregulation in obesity. In this context, the group uses a multidisciplinary approach based on the study of mouse models for the characterisation of the dynamic changes that occur in the specialised lipid storage organelle when facing situations of extreme lipid overloading as seen in obesity. Members of the group are co-foundation members of the French Association for the Study and Research on of Obesity (AFERO). The group has developed methodology for isolating pure and intact lipid droplet fractions from primary adipocytes. The tasks in the proposal combine the knowledge in the physiopathology of animal models with metabolic phenotypes and validated

experience of the technologies of adipocyte lipid droplet preparation.
ContributionsThe partner will be responsible to determine the regulation of lipid droplet formation with regard to cross talk between subcutaneous and mental adipose tissue in obesity and insulin resistance by analyzing changes in gene expression, protein and lipid composition.
Member of TaskforcesTask Force I, Task Force II, Task Force III, Task Force V, Task Force VII, and Task Force IX
Member of WorkpackagesWP3

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