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InstitutionThe Babraham InstituteImage:P13_Babraham_Inst.jpg
Principal investigator Prof. Dr. Michael Wakelam

Email: Michael Wakelam

Telephone:+44 1223-496202
Country United Kingdom
Beneficiary NumberP13
About usThe Babraham Institute is an independent charitable life sciences Institute, sponsored by the

BBSRC, carrying out world-leading innovative research and advanced training with relevance to the biomedical, biotechnological, pharmaceutical and healthcare research and user communities. The research focuses on the mechanisms of cell signalling and gene regulation which underlie normal cellular processes and functions, and on how their failure or abnormality may lead to disease. The signalling research has a particular focus upon lipid signalling with phospholipases and PI-3-kinases being major areas, though MAP kinase signalling is also a key area. The Institute is core funded by the BBSRC and additionally researchers are funded by the MRC, British Heart Foundation, Wellcome Trust, Cancer Research UK, Leukaemia Research fund and the EU, as well as attracting significant industrial funding. The modern research laboratories are well equiped and house more than 300 scientists. Core facilities include mass spectrometry, protein production equipment, imaging, FACS, animal houses and gene analysis. The Wakelam laboratory has long and extensive experience in the analysis of lipids and has established the CR-UK Lipidomic Oncology Program within the Institute. In WP4 Babraham scientists will collaborate closely with Professor Mark McCarthy and Dr Frederik Karpe of the University of Oxford Centre for Diabetes, Endocrinology and Metabolism, and Dr John Mclauchlan, MRC Virology Unit, Glasgow. Professor Wakelam retains an honorary professorial appointment at the University of Birmingham where he collaborates extensively with Professor David Adams, of the

University of Birmingham Liver Unit who provides clinical material.
ContributionsThe Wakelam laboratory brings expertise in the study of signal transduction

pathways to LipidomicNet. The lab has developed HPLC-MS methods for the analysis of lipids including the phosphoinositides. The lab has expertise in the generation of genetically modified mouse models and through association with Birmingham University access to human samples and

DNA array facilities.
Member of TaskforcesTask Force I, Task Force II, Task Force VI, Task Force VII, and Task Force IX
Member of WorkpackagesWP4

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