From LipidomicsWiki

Jump to: navigation, search
InstitutionMRC Virology UnitImage:P23_uni_glasgow.gif
Principal investigator Dr. John McLauchlan

Email: John McLauchlan

Telephone:+44 (0)141 330 4017
Country United Kingdom
Beneficiary NumberP23
About usResearch at the Medical Research Council (MRC) Virology Unit, based at the Universirty of

Glasgow, focuses on conducting studies into viruses of importance in human disease. A major component of the research effort is the study of hepatitis C virus (HCV) with the purpose of combining fundamental and clinical aspects of virus infection. The McLauchlan laboratory has gained international recognition for its studies on the role of lipid droplets and lipid biosynthesis in the virus life cycle. It is also engaged in determining the contribution of HCV infection and the individual viral components to the development of metabolic disorders in humans infected with the virus, with particular emphasis on the mechanisms that lead to steatosis. The Virology Unit is fully equipped for molecular studies on viruses and includes a CL3 suite, confocal microscopes, facilities for live cell imaging and a state-of-the-art electron microscope for EM tomography. The McLauchlan laboratory has extensive experience in the handling and propagation of HCV (under CL3 conditions), cell biology, biophysical studies in live cells and molecular biology. For several years, they have investigated the interaction of the HCV core protein, which forms the virus capsid, with lipid droplets and recently

established that this association is critical for production of infectious HCV.
ContributionsThe McLauchlan laboratory will bring expertise in the study of hepatitis C virus (HCV) to LipidomicNet. This includes extensive virology, cell biology and molecular biology. Our aim is to understand the role of lipid metabolism, including the contribution of lipid droplets, in HCV infection.
Member of TaskforcesTask Force II, Task Force VI, and Task Force IX
Member of WorkpackagesWP4

Back to List of Beneficiaries

Personal tools
Create a book